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KMID : 0385520090220040319
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Analytical Science & Technology
2009 Volume.22 No. 4 p.319 ~ p.325
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Analysis of residual neomycin in honey by LC-MS/MS
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Shim Young-Eun
Jeong Ji-Yoon
Myung Seung-Woon
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Abstract
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An effective and specific procedure for confirmation of neomycin, aminoglycoside antibiotic in honey was developed and validated. Honey was adjusted to pH 2 with 0.1M HCl and applied to weak cation-exchange SPE cartridge. Neomycin was eluted with basified methanol. Following separation by ion-pairing liquid chromatography, neomycin was analysed with positive electrospray ionization and MRM mode. Quantification was linear over the range of 5.0~250.0 ㎍/㎏ (r2＞0.9951). The precision (R.S.D.) and accuracy (as a bias) of quality control samples in honey ranged 11.5~18.7% and 10.9~20.9%, respectively. Established method can be applied to analysis of neomycin in honey.
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KEYWORD
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Honey, neomycin, LC-MS/MS
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